Levels and in-unit stability of 11-nor-9-carboxy-9-tetrahydrocannabinol (9-carboxy-THC) in donor platelets and whole blood: is enough present to have an impact on recipients?

Abstract Objective The safety of the United States donor blood supply has been questioned in context recreational marijuana legalization Colorado and other states nationwide. It is unclear whether cannabis use by donors presents a danger to recipients, either through direct toxicity or socioeconomic ramifications. Our objectives are both determine if active metabolite tetrahydrocannabinol (THC), 11-nor-9-carboxy-9-tetrahydrocannabinol (9-carboxy-THC), present donated units dosage high enough impact recipient assess for in-unit metabolism degradation. Methods We will quantify amount 9-carboxy-THC platelet self-reported users liquid chromatography with tandem mass spectrometry (LC-MS/MS) testing correlate assay data survey responses. To gain insight into stability, we also test whole at several time points throughout storage, collected from participants who self-report taking known oral dose THC prior donation. Results Institutional review board approval study evaluating children’s hospital presented challenge, requiring addition an organizational risk update transfusion consent approval. Thus, projected timeline this extended. Study recruitment flyers email screening have generated interest volunteer donors. was sent 9,208 had previously least once, which received 372 responses (4.04% response rate). Of respondents, 49 individuals reported daily use, 33 usage 4-6 times per week, 32 1-3 times/week, 30 times/month, 52 rare usage, 167 never using marijuana. Overall, out over 50% some 31% weekly usage. Although number small, our found that many were repeat Research visits currently being scheduled interested participants. Conclusions This highlights challenges performing research illustrates why there lack published effects legalization. completion project investigating controversial topic delayed, persistent advocation area opening doors future studies hopefully pave way fill knowledge gaps. results inform decisions regarding eligibility national as well address associated implications.